Quantitative analysis of Epstein-Barr Virus (EBV) antibody levels provides valuable insights into the stage and nature of infection. Different antibody types, such as IgG, IgM, and IgA against specific viral antigens (e.g., viral capsid antigen, early antigen), are measured. These measurements, typically expressed in units per milliliter or as a ratio against a standard, help clinicians distinguish between acute, recent, or past infections. For example, high IgM levels might suggest a recent or current infection, while elevated IgG levels, especially against specific EBV nuclear antigen, indicate past exposure and immunity.
Understanding the spectrum of possible antibody levels is critical for accurate EBV infection diagnosis and management. It allows for differentiation between various stages of infection and helps avoid misdiagnosis. Historically, the development of serological assays to detect EBV antibodies revolutionized the understanding of the viruss epidemiology and its association with various diseases, including infectious mononucleosis and certain cancers. This knowledge underpins modern diagnostic strategies and guides treatment decisions.